850405-00-4

Basic information

• Product Name: 4-Pentene-1,2-diol, 3-(dimethylphenylsilyl)-, (2S,3S)-
• CAS NO: 850405-00-4
• Molecular Formula: C13H20O2Si
• Molecular Weight: 236.386
• Mol File: 850405-00-4.mol

Chemical Properties

• CAS DataBase Reference: 4-Pentene-1,2-diol, 3-(dimethylphenylsilyl)-, (2S,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pentene-1,2-diol, 3-(dimethylphenylsilyl)-, (2S,3S)-(850405-00-4)
• EPA Substance Registry System: 4-Pentene-1,2-diol, 3-(dimethylphenylsilyl)-, (2S,3S)-(850405-00-4)

Safety Data

• Hazardous Substances Data: 850405-00-4(Hazardous Substances Data)

Upstream product

• 171868-02-3 [(2S,3S)-3-(dimethyl-phenyl-silanyl)-oxiran-2-yl]methanol 
• 101844-21-7 (E)-3-[(dimethyl)phenylsilyl]prop-2-en-1-ol 
• 766-77-8 Dimethylphenylsilane 
• 913193-83-6 (2S,3S)-2-(Dimethyl-phenyl-silanyl)-3-trimethylsilanyloxymethyl-oxirane 

Downstream Products

• 850405-01-5 2,4,6-Trimethyl-benzenesulfonic acid (2S,3S)-3-(dimethyl-phenyl-silanyl)-2-hydroxy-pent-4-enyl ester 
• 321667-28-1 (1R,3S,5R,7R,9R,13R,15S,18S)-7-(tert-butyldiphenylsilanyloxy)-3-methoxy-18-methyl-13-((E)-4-methylpent-1-enyl)-12,19,20-trioxatricyclo[13.3.1.1^5,9]icosan-11-one 
• 850404-91-0 2,4,6-trimethylbenzenesulfonic acid (2R,6S)-6-((R)-4-benzyloxy-2-methoxybutyl)-5,6-dihydro-2H-pyran-2-ylmethyl ester 
• 850404-99-8 {(2S,4S,6R)-4-(tert-butyldiphenylsilanyloxy)-6-[(2S)-3-((2R,3S,6S)-6-((2R,3E)-2-hydroxy-6-methylhept-3-enyl)-3-methyltetrahydro-2H-pyran-2-yl)-2-methoxypropyl]tetrahydro-2H-pyran-2-yl}acetonitrile 
• 862846-88-6 (1R,3S,5R,7R,9R,13R,15S,18S)-7-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-18-methyl-13-((E)-4-methyl-pent-1-enyl)-12,19,20-trioxa-tricyclo[13.3.1.1^5,9]icosan-11-ol 
• 850404-97-6 (2S,5S,6R)-6-{(2S)-3-[(2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-cyanomethyltetrahydro-2H-pyran-2-yl]-2-methoxypropyl}-5-methyltetrahydro-2H-pyran-2-carboxylic acid isopropyl ester 
• 850404-96-5 (2S,5S,6R)-6-{(2S)-3-[(2R,4S,6S)-4-(tert-butyldiphenylsilanyloxy)-6-cyanomethyltetrahydro-2H-pyran-2-yl]-2-methoxypropyl}-5-methyl-5,6-dihydro-2H-pyran-2-carboxylic acid isopropyl ester 
• 850404-85-2 {(2S,4S,6R)-4-(tert-butyldiphenylsilanyloxy)-6-[(2S)-2-methoxy-3-((2R,3S,6S)-3-methyl-6-(oxoethyl)tetrahydro-2H-pyran-2-yl)propyl]tetrahydro-2H-pyran-2-yl}acetonitrile 

Relevant articles and documents

[4 + 2]-Annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A

Complete details of an asymmetric synthesis of leucascandrolide A (1) are described. The synthesis highlights the use of two diastereoselective [4 + 2]-annulations for the assembly of the functionalized bispyranyl macrolide 3. An efficient assembly and un