850405-07-1Relevant academic research and scientific papers
Stereoselective syntheses of 11-α-methoxycurvularin and 11-β-methoxycurvularin
Venkateswar Reddy,Sateesh Chandra Kumar,Suresh Babu,Madhusudana Rao
scheme or table, p. 4117 - 4120 (2009/12/01)
A stereoselective synthesis of potent cytotoxic macrolides, 11-α-methoxycurvularin and 11-β-methoxycurvularin has been accomplished. The synthesis entailed Maruoka asymmetric allylation to introduce the stereocentres at C-11 and the key fragment was insta
[4 + 2]-Annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A
Su, Qibin,Dakin, Les A.,Panek, James S.
, p. 2 - 24 (2007/10/03)
Complete details of an asymmetric synthesis of leucascandrolide A (1) are described. The synthesis highlights the use of two diastereoselective [4 + 2]-annulations for the assembly of the functionalized bispyranyl macrolide 3. An efficient assembly and un
Total synthesis of (+)-leucascandrolide A
Su, Qibin,Panek, James S.
, p. 1223 - 1225 (2007/10/03)
A convergent and enantioselective total synthesis of (+)-leucascandrolide (1) was accomplished in 17 steps. Central to this synthesis is the rapid and efficient integration of the bispyran moiety into 1 using two consecutive [4 + 2] annulation reactions b
