850405-34-4

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 1408314-20-4 4-(2-amino-6-(2-nitrophenyl)-6H-1,3-thiazin-4-yl)phenol 
• 850405-28-6 Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-{4-[2-mercapto-6-(2-nitro-phenyl)-5,6-dihydro-pyrimidin-4-yl]-phenoxy}-tetrahydro-pyran-3-yl ester 
• 850405-20-8 4-[2-mercapto-6-(2-nitro-phenyl)-5,6-dihydro-pyrimidin-4-yl]-phenol 

Relevant academic research and scientific papers

Design, Synthesis, Antibacterial Activity, and Molecular Docking Studies of Novel Hybrid 1,3-Thiazine-1,3,5-Triazine Derivatives as Potential Bacterial Translation Inhibitor

Some novel hybrid 1,3-thiazine-1,3,5-triazine derivatives were synthesized and tested for antibacterial activity. Compounds 8c and 8f were found active against Gram positive and Gram negative microorganisms. Molecular docking studies have been performed o

Design, synthesis, biological evaluation of 3,5-diaryl-4,5-dihydro-1H-pyrazole carbaldehydes as non-purine xanthine oxidase inhibitors: Tracing the anticancer mechanism via xanthine oxidase inhibition

Xanthine oxidase (XO) has been primarily targeted for the development of anti-hyperuriciemic /anti-gout agents as it catalyzes the conversion of xanthine and hypoxanthine into uric acid. XO overexpression in various cancer is very well correlated due to r

The synthesis and mesomorphic properties of a novel homologous series: α-4-[4′-n-alkoxy benzoyloxy] benzoyl-β-2″-nitro phenyl ethylenes

The synthesis and mesomorphic properties of novel homologous series are reported. All 11 members of the series, except the methoxy and ethoxy derivatives, are enantiotropically mesogenic. The propoxy to tetradecyloxy homologues exhibits smectognic amd nematogenic behavior, while the hexadecyloxy homologue shows only nematogenic behavior. An odd-even effect is observed for the smectic-nematic and the nematic-isotropic transition curve in the phase diagram. Analytical data support the structure of molecules. The textures of the nematic mesophase are threaded or Schlieren, and that of smectic mesophase are of type-A. The transition temperatures of homologues and other mesomorphic properties are determined using optical polarizing microscopy. The smectic and nematic thermal stabilities are 138.0°C and 163.8°C respectively. The novel series is predominantly nematogenic and partly smectogenic with middle-ordered melting type. The nematic and smectic phase ranges vary between 16°C and 38°C and 6°C and 22°C respectively. The mesogenic properties of the novel series are compared with other structurally similar homologous series.

Glucosylation of 4′-hydroxychalcones using glucosyl donor

Condensation of α-acetobromoglucose with 4′- hydroxyarylmethyleneacetophenone derivatives (chalcones) in anhydrous acetone furnishes 2,3,4,6-tetra-O-acetyl-4′-O-β-D-glucopyranosyloxychalcones. Deblocking of the latter with CH3ONa in dry methanol affords 4′-O-β-D-glucopyranosyloxychalcones. The structure of these products have been assigned on the basis of their sophisticated instrumental analysis like IR, 1H NMR, 13C NMR, FAB-MS, specific rotation, elemental analysis and chemical properties.