850409-29-9Relevant academic research and scientific papers
Structure-activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors
Wan, Sheng Biao,Landis-Piwowar, Kristin R.,Kuhn, Deborah J.,Chen, Di,Dou, Q. Ping,Chan, Tak Hang
, p. 2177 - 2185 (2007/10/03)
The structure-activity relationship of a number of synthetic green tea polyphenol analogs involving modifications of A ring and B ring of epi-gallocatechin gallate (EGCG) as proteasome inhibitors has been examined. It was found that in B ring, a decrease in the number of OH groups led to decreased potency. Introduction of a hydrophobic benzyl group into the 8 position of A ring did not significantly affect the proteasome-inhibitory potency.
