850416-19-2

Upstream product

• 109-87-5 Dimethoxymethane 
• 95112-81-5 (S)-ethyl 5-benzyloxy-3-hydroxypentanoate 
• 64714-79-0 5-benzyloxy-3-oxo-pentanoic acid ethyl ester 

Downstream Products

• 850416-11-4 7-benzyloxy-5-methoxymethoxy-3-oxo-heptanoic acid tert-butyl ester 
• 850416-15-8 (E)-(2S,3S,4R,9S,11S)-13-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-11-methoxymethoxy-2,4-dimethyl-7-oxo-3-triisopropylsilanyloxy-tridec-5-enoic acid tert-butyl ester 
• 850416-22-7 (E)-(2S,3S,4R,9S,11S)-13-Benzyloxy-9-hydroxy-11-methoxymethoxy-2,4-dimethyl-7-oxo-3-triisopropylsilanyloxy-tridec-5-enoic acid tert-butyl ester 
• 850416-14-7 [(4S,6S)-8-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-6-methoxymethoxy-2-oxo-octyl]-phosphonic acid diethyl ester 
• 850416-21-6 [(4R,6S)-8-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-methoxymethoxy-octyl]-phosphonic acid diethyl ester 
• 850416-20-5 7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxymethoxy-heptanoic acid tert-butyl ester 
• 850416-13-6 (3S,5S)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxymethoxy-heptanal 
• 850416-12-5 (3S,5S)-7-Benzyloxy-3-hydroxy-5-methoxymethoxy-heptanoic acid tert-butyl ester 

Relevant academic research and scientific papers

First stereoselective synthesis of the C(1)-C(13) fragment of dolabelides using ruthenium-SYNPHOS-catalyzed asymmetric hydrogenation reactions

The first stereocontrolled synthesis of the C(1)-C(13) fragment of cytotoxic macrolides dolabelides is reported. The C(3), C(7), C(9) and C(11) hydroxyl-bearing stereocenters were installed using ruthenium-mediated asymmetric hydrogenation reactions of the adequate β-keto esters and β-hydroxy ketone. Georg Thieme Verlag Stuttgart.