850452-10-7Relevant academic research and scientific papers
Hydrogen atom transfer methodology for the synthesis of C-22, C-23, and C-25 stereoisomers of cephalostatin north 1 side chain from spirostan sapogenins
Betancor, Carmen,Freire, Raimundo,Pérez-Martín, Inés,Prangé, Thierry,Suárez, Ernesto
, p. 2803 - 2814 (2005)
A simple synthesis of all eight C-22, C-23, and C-25 diastereoisomers of the cephalostatin north 1 side chain has been accomplished from (25R)-5α-spirostan-3β-ol (tigogenin). The synthesis involves selective hydroxylations at C-23 and C-25 and reductive o
