85048-42-6Relevant articles and documents
Chiral cycloalkylidene α,β-unsaturated iminium approach to stereoselective formal [3+3] cycloaddition reaction in spiroheterocycle synthesis
McLaughlin, Michael J.,Shen, Hong C.,Hsung, Richard P.
, p. 609 - 613 (2001)
An approach to stereoselective formal [3+3] cycloaddition reaction using chiral cycloalkylidene α,β-unsaturated iminiums is described here leading to preparations of spiroheterocycles in modest stereoselectivity. The reversibility of 6π-electron electrocyclic ring closure did not always lead to the thermodynamically more favored product. These observations led to other useful mechanistic understanding of electrocyclic ring closure of 1-oxatrienes.
A Novel and Highly Stereoselective Approach to Aza-Spirocycles. A Short Total Synthesis of 2-epi-(±)-Perhydrohistrionicotoxin and an Unprecedented Decarboxylation of 2-Pyrones
McLaughlin, Michael J.,Hsung, Richard P.,Cole, Kevin P.,Hahn, Juliet M.,Wang, Jiashi
, p. 2017 - 2020 (2007/10/03)
(Matrix Presented) A novel and highly stereoselective synthesis of aza-spirocycles is described. An application of this methodology is illustrated as a short and concise total synthesis of 2-epi-(±)-perhydrohistrionicotoxin with high diastereomeric contro
