850568-51-3 Usage
General Description
1-BOC-6-Methylindole-2-boronic acid is a chemical compound with the molecular formula C14H18BNO4. It is a boronic acid derivative with a BOC (tert-butoxycarbonyl) protecting group and a methyl group attached to the 6-position of the indole ring. 1-BOC-6-METHYLINDOLE-2-BORONIC ACID is commonly used in organic synthesis as a building block in the preparation of various pharmaceuticals, agrochemicals, and materials. It is a valuable reagent for Suzuki-Miyaura cross-coupling reactions, which are widely used in organic chemistry for the formation of carbon-carbon bonds. Additionally, 1-BOC-6-Methylindole-2-boronic acid is a versatile intermediate for the synthesis of various heterocyclic compounds and functionalized indole derivatives with potential biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 850568-51-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,0,5,6 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 850568-51:
(8*8)+(7*5)+(6*0)+(5*5)+(4*6)+(3*8)+(2*5)+(1*1)=183
183 % 10 = 3
So 850568-51-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H18BNO4/c1-9-5-6-10-8-12(15(18)19)16(11(10)7-9)13(17)20-14(2,3)4/h5-8,18-19H,1-4H3
850568-51-3Relevant articles and documents
Structure-activity relationship (SAR) optimization of 6-(Indol-2-yl) pyridine-3-sulfonamides: Identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B
Zhang, Nanjing,Zhang, Xiaoyan,Zhu, Jin,Turpoff, Anthony,Chen, Guangming,Morrill, Christie,Huang, Song,Lennox, William,Kakarla, Ramesh,Liu, Ronggang,Li, Chunshi,Ren, Hongyu,Almstead, Neil,Venkatraman, Srikanth,Njoroge, F. George,Gu, Zhengxian,Clausen, Valerie,Graci, Jason,Jung, Stephen P.,Zheng, Yingcong,Colacino, Joseph M.,Lahser, Fred,Sheedy, Josephine,Mollin, Anna,Weetall, Marla,Nomeir, Amin,Karp, Gary M.
, p. 2121 - 2135 (2014/04/03)
A novel, potent, and orally bioavailable inhibitor of hepatitis C RNA replication targeting NS4B, compound 4t (PTC725), has been identified through chemical optimization of the 6-(indol-2-yl)pyridine-3-sulfonamide 2 to improve DMPK and safety properties.
