850607-63-5Relevant academic research and scientific papers
Design, synthesis, and structure - Activity relationship of tropane muscarinic acetylcholine receptor antagonists
Lainé, Dramane I.,Wan, Zehong,Yan, Hongxing,Zhu, Chongjie,Xie, Haibo,Fu, Wei,Busch-Petersen, Jakob,Neipp, Christopher,Davis, Roderick,Widdowson, Katherine L.,Blaney, Frank E.,Foley, James,Bacon, Alicia M.,Webb, Edward F.,Luttmann, Mark A.,Burman, Miriam,Sarau, Henry M.,Salmon, Michael,Palovich, Michael R.,Belmonte, Kristen
, p. 5241 - 5252 (2009)
Novel tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs). Through optimization of the structure - activity relationship around the tropane scaffold, the quaternary ammonium salt 34 was identified as a very pot
