850616-48-7Relevant academic research and scientific papers
Structure-activity relationships of the cycloalkanol ethylamine scaffold: Discovery of selective norepinephrine reuptake inhibitors
Mahaney, Paige E.,Gavrin, Lori K.,Trybulski, Eugene J.,Stack, Gary P.,Vu, An T.,Cohn, Stephen T.,Ye, Fei,Belardi, Justin K.,Santilli, Arthur A.,Sabatucci, Joseph P.,Leiter, Jennifer,Johnston, Grace H.,Bray, Jenifer A.,Burroughs, Kevin D.,Cosmi, Scott A.,Leventhal, Liza,Koury, Elizabeth J.,Zhang, Yingru,Mugford, Cheryl A.,Ho, Douglas M.,Rosenzweig-Lipson, Sharon J.,Platt, Brian,Smith, Valerie A.,Deecher, Darlene C.
experimental part, p. 4038 - 4049 (2009/05/07)
Further exploration of the cycloalkanol ethylamine scaffold, of which venlafaxine (1) is a member, was undertaken to develop novel and selective norepinephrine reuptake inhibitors (NRIs) for evaluation in a variety of predictive animal models. These effor
1- 2’ (1, 4’-BIPERIDIN-1’-YL)-1- (PHENYL) -ETHYL CYCLOHEXANOL DERIVATIVES AS MONOAMINE REUPTAKE MODULATORS FOR THE TREATMENT OF VISOMOTOR SYMPTOMS
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Page/Page column 78, (2008/06/13)
The present invention is directed to substituted N-heterocycle derivatives of formula (I), compositions containing these derivatives, and their use in the manufacture of a medicament for the prevention and treatment of conditions ameliorated by monoamine
FUSED-ARYL AND HETEROARYL DERIVATIVES AND METHODS OF THEIR USE
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Page/Page column 78, (2008/06/13)
The present invention is directed to fused-aryl and heteroaryl derivatives of formula I, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter
Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use
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Page/Page column 24-25, (2010/02/14)
The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including,
ALKANOL AND CYCLOALKANOL-AMINE DERIVATIVES AND METHODS OF THEIR USE
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Page/Page column 65, (2008/06/13)
The present invention is directed to alkanoyl and cycloalkanoyl-amine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia,
SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE
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Page/Page column 80, (2008/06/13)
The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia,vas
