85064-07-9Relevant academic research and scientific papers
Metal halide hydrates as lewis acid catalysts for the conjugated Friedel-Crafts reactions of indoles and activated olefins
Schwalm, Cristiane S.,Ceschi, Marco Antonio,Russowsky, Dennis
, p. 623 - 636 (2012/01/05)
Metal halide hydrates such as SnCl2·2H2O, MnCl2·4H2O, SrCl2·6H 2O, CrCl2·6H2O, CoCl2· 6H2O e CeCl3·7H2O were investigated as mild Lewis acids catalysts for the conjugate Friedel-Crafts reaction between indoles and activated olefins. The reactions were carried out with aliphatic unsaturated ketones over a period of days at room temperature, while chalcones reacted only under reflux conditions. The reactions with nitrostyrenes were either performed in solvent or under solventless conditions. In all cases reasonable to good yields were obtained. ?2011 Sociedade Brasileira de Qui?mica.
Boric acid-mediated mild and efficient friedel-crafts alkylation of indoles with nitro styrenes
Meshram,Rao, N. Nageswara,Kumar, G. Santosh
experimental part, p. 3496 - 3500 (2011/02/22)
An efficient method has been developed for the synthesis of indole 3-derivatives by the Friedel-Crafts alkylation of indole with nitro olefins in presence of boric acid in aqueous medium. Copyright Taylor & Francis Group, LLC.
Silica gel, an effective catalyst for the reaction of electron-deficient nitro-olefins with nitrogen heterocycles
Shumaila, Abdullah M. A.,Kusurkar, Radhika S.
experimental part, p. 2935 - 2940 (2010/10/20)
The reaction of electron-deficient olefins with nitrogen heterocycles such as pyrrole and indole was examined in the presence of silica gel at room temperature under stirring at solvent-free conditions. It was found that silica gel is an effective catalys
Use of the Pictet-Spengler reaction for the synthesis of 1,4-disubstituted-1,2,3,4-tetrahydro-β-carbolines and 1,4-disubstituted-β-carbolines: formation of γ-carbolines
Kusurkar, Radhika S.,Alkobati, Nabil A.H.,Gokule, Anita S.,Puranik, Vedavati G.
, p. 1654 - 1662 (2008/09/17)
Microwave-assisted conjugate addition of indole on nitro-olefins furnished nitro compounds, which were reduced to tryptamines. Further, by using Pictet-Spengler condensation, new 1,4-disubstituted-1,2,3,4-tetrahydro-β-carbolines were synthesized in diaste
Thermal and microwave-assisted conjugate additions of indole on electron-deficient nitro-olefins
Kusurkar, Radhika S.,Alkobati, Nabil A. H.,Gokule, Anita S.,Chaudhari, Purnima M.,Waghchaure, Prasad B.
, p. 1075 - 1081 (2007/10/03)
Conjugate addition of indole on nitro-olefins was carried out by three different methods: (i) thermal heating in a sealed tube, (ii) reaction with indolyl magnesium iodide, and (iii) microwave irradiation. Comparison of the results indicated that the micr
