850640-10-7Relevant academic research and scientific papers
1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors
Mulvihill, Mark J.,Ji, Qun-Sheng,Werner, Doug,Beck, Patricia,Cesario, Cara,Cooke, Andrew,Cox, Matthew,Crew, Andrew,Dong, Hanqing,Feng, Lixin,Foreman,Mak, Gilda,Nigro, Anthony,O'Connor, Matthew,Saroglou, Lydia,Stolz, Kathryn M.,Sujka, Izabela,Volk, Brian,Weng, Qinghua,Wilkes, Robin
, p. 1091 - 1097 (2007/10/03)
A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.
IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS
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Page/Page column 141, (2008/06/13)
Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
