850641-86-0Relevant academic research and scientific papers
Synthesis of 2-aryl-4-chloropyrroles via ring expansion of 2-aryl-1-chlorocyclopropanecarbaldehydes
Verniest, Guido,Claessens, Sven,Bombeke, Filip,Van Thienen, Tinneke,De Kimpe, Norbert
, p. 2879 - 2887 (2007/10/03)
An efficient electrophile-induced ring opening of 2-aryl-1- chlorocyclopropanecarbaldehydes is described towards halogenated butanals, which were converted to the corresponding imines. These α,α,γ- trichloroimines proved to be good substrates for a nucleophile-induced ring closure towards 2-pyrrolines as versatile synthons for the synthesis of pyrroles bearing physiologically interesting substitution patterns.
