850695-43-1Relevant articles and documents
Phosphine-catalyzed synthesis of 1,3-dioxan-4-ylidenes
Zhu, Xue-Feng,Henry, Christopher E.,Wang, Jay,Dudding, Travis,Kwon, Ohyun
, p. 1387 - 1390 (2005)
(Chemical Equation Presented) A phosphine-catalyzed reaction of an allenoate with aldehydes furnished (2,6-diaryl-[1,3]dioxan-4-ylidene)-acetates 4 in excellent to moderate yields with complete diastereoselectivity and high E/Z-selectivities. Upon removal of the acetal functionality in this domino reaction product 4, δ-hydroxy-β-ketoester 11 was obtained. The reported vinylphosphonium-based approach provides a new way to achieve a synthesis of δ-hydroxy-β-ketoesters that differs from the classical dianion-based approach.