85070-48-0

Basic information

• Product Name: 3-Chloro-2-fluorobenzaldehyde
• Synonyms: 3-CHLORO-2-FLUOROBENZALDEHYDE;TIMTEC-BB SBB003987;3-Chloro-2-fluorobenzaldehyde 97%;3-Chloro-2-fluorobenzaldehyde97%;2-fluoro-3-chloro-benzaldehyde;3-Chloro-2-Flourobenzaldehyde;Benzaldehyde,3-chloro-2-fluoro-
• CAS NO: 85070-48-0
• Molecular Formula: C₇H₄ClFO
• Molecular Weight: 158.56
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Aryl;Building Blocks;Fluorinated;Aldehydes;C7;Carbonyl Compounds
• Mol File: 85070-48-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 214 °C(lit.)
• Flash Point: 186 °F
• Appearance: light yellow liquid
• Density: 1.35 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.16mmHg at 25°C
• Refractive Index: n20/D 1.545(lit.)
• Storage Temp.: Refrigerator
• Sensitive: Air Sensitive
• BRN: 5861249
• CAS DataBase Reference: 3-Chloro-2-fluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2-fluorobenzaldehyde(85070-48-0)
• EPA Substance Registry System: 3-Chloro-2-fluorobenzaldehyde(85070-48-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 85070-48-0(Hazardous Substances Data)

Usage

Chemical Properties

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Uses

3-Chloro-2-fluorobenzaldehyde is an intermediate used to synthesize small-molecule inhibitors of MDM2-p53 interaction as antitumor agents. It is also used to prepare flavonoid derivatives as selective neuromedin U 2 receptor agonists for obesity treatment.

General Description

3-Chloro-2-fluorobenzaldehyde is a fluorinated benzaldehyde derivative.

InChI:InChI=1/C7H4ClFO/c8-6-3-1-2-5(4-10)7(6)9/h1-4H

Upstream product

• 85070-47-9 1-(bromomethyl)-3-chloro-2-fluorobenzene 
• 79-46-9 2-nitropropane 
• 261723-30-2 (3-chloro-2-fluorophenyl)methanol 
• 94087-40-8 3-chloro-2-fluorobenzonitrile 
• 6574-97-6 2,3-dichlorobenzonitrile 
• 85089-31-2 3-chloro-2-fluorotoluene 

Downstream Products

• 550998-56-6 7-chloro-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 699016-13-2 N-[(1R)-2-[4-[(2-chloro-6-formylphenyl)-thio]phenyl]-1-methylethyl]-2,2,2-trifluoroacetamide 
• 878001-21-9 (3-chloro-2-fluorobenzyl)cyclopropylamine 

Relevant articles and documents

A 2-fluoro-3-chlorobenzene process for the preparation of formaldehyde

The invention relates to the field of fine chemical intermediates, in particular to a preparation method for 2-fluoro-3-chlorobenzaldehyde, namely, a fluorine-containing medical intermediate. According to the method, 2,3-dichlorobenzonitrile serves as raw materials, and 2-fluoro-3-chlorobenzaldehyde is obtained after fluorination, hydrolysis, oxidation and reduction are conducted. The method is low in raw material cost, high in apparent availability, mature and stable in reaction technology, high in operability and beneficial to industrial production.

DIAMINE DERIVATIVES

A compound represented by formula (1):Q1-Q2-To-N(R1) -Q3-N(R2)-T1-Q4 [wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group: (wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

DIAMINE DERIVATIVES

A compound represented by the general formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.