85071-34-7Relevant academic research and scientific papers
Remarkable ketene substituent dependent effect of photo irradiation on the diastereoselectivity in the Staudinger reaction
Yang, Zhanhui,Xu, Jiaxi
, p. 786 - 789 (2012)
Controlling diastereoselectivity is a challenging issue in the Staudinger reaction. The influence of ultraviolet irradiation on the stereoselectivity in the Staudinger reaction has been investigated. The results indicate that ultraviolet irradiation is on
Hypocholesterolemic activity of some novel azetidin-2-ones in diet and diabetes induced hypercholesterolemia in rats
Goel,Thind,Bal,Mahajan,Kulkarni
, p. 369 - 374 (2007/10/03)
Some novel substituted azetidin-2-ones (5-8) were synthesized via {2 + 2} cycloaddition reactions of imines and ketenes and evaluated for their ability to prevent diet and diabetes induced hypercholesterolemia. The test compounds 5a and 7a significantly (p a dose dependent manner. Compound 5a also raised the high density lipoprotein-cholesterol levels in chronic diet models by peanut oil (5.5%), cholesterol (1.5%) and cholic acid (0.5%). In a diabetes induced model of hypercholesterolemia, the test compounds were evaluated for preventing diabetes-induced hypercholesterolemia (protocol 1) as well as for lowering post diabetic hypercholesterolemia (protocol 2). Test compounds 5a-g and 7a-d significantly (p a greater reduction in protocol 1 as compared with protocol 2. Based on SAR studies, the substituents that favor hypocholesterolemic activity around the azetidin-2-one nucleus are discussed and a possible mechanism of action is proposed on the basis of their differential effects in two protocols of diabetes-induced hypercholesterolemia.
TRIPHENYLPHOSPHINE DIBROMIDE AND DIMETHYLSULFIDE DIBROMIDE AS VERSATILE REAGENTS FOR BETA-LACTAM SYNTHESIS
Cossio, Fernando P.,Ganboa, Inaki,Palomo, Claudio
, p. 3041 - 3044 (2007/10/02)
Triphenylphosphine dibromide and dimethylsulfide dibromide are efficient reagents for the direct synthesis of beta-lactams from carboxylic acids and imines avoiding the use of acid halides as starting materials.Synthesis of 4-imino-beta-lactams are also briefly described.A potential synthesis of N-unsubstituted beta-lactams is made.
