850715-33-2

Upstream product

• 143724-90-7 (2R)-1-chloro-5-(trimethylsilyl)pent-4-yn-2-ol 
• 640270-65-1 (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}hex-5-ynenitrile 
• 640270-59-3 (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}hex-5-ynal 
• 182681-88-5 (2R)-1-cyano-2-hydroxy-4-pentyne 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 850715-39-8 (1S,3R,4S)-3-(methoxymethoxy)-4-methyl-1-[3-(triisopropylsilyl)prop-2-ynyl]hept-6-enyl 2-allyl-6-methoxybenzoate 
• 850715-35-4 (2R,3R,5R)-2-allyl-5-{[tert-butyl(dimethyl)silyl]oxy}-3-(methoxymethoxy)oct-7-ynyl 4-methylbenzenesulfonate 
• 850715-38-7 (1S,3R,4S)-3-(methoxymethoxy)-4-methyl-1-(prop-2-ynyl)hept-6-enyl 2-allyl-6-methoxybenzoate 

Relevant academic research and scientific papers

Synthesis of the salicylihalamide core structure from epichlorohydrin - Laying the foundation to macrolactone collections

Starting from (R)-epichlorohydrin, two successive carbon-carbon bond formations, one with acetylide and the other with cyanide, led to the 3′-hydroxynitrile 20. This compound was further elaborated to the enynol 29 via an Evans aldol reaction of the deriv