850716-40-4

Upstream product

• 931-33-9 4-bromopyrrole-2-carboxaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 
• 68-12-2 N,N-dimethyl-formamide 
• 1003-29-8 2-pyrrole aldehyde 

Downstream Products

• 177949-82-5 4-Phenyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde 
• 946847-32-1 C₁₇H₁₄N₂O₃S 
• 946847-33-2 C₁₉H₁₅NO₅S 
• 946847-34-3 C₁₉H₁₇NO₄S 
• 946847-35-4 C₁₈H₁₄FNO₃S 
• 946847-36-5 C₁₉H₁₇NO₃S 
• 946847-37-6 C₁₉H₁₆N₂O₄S 
• 946847-38-7 C₂₀H₁₈N₂O₄S 
• 946847-39-8 C₁₉H₁₈N₂O₃S 
• 850716-41-5 4-(3-methoxyphenyl)-2-pyrrolecarboxaldehyde 

Relevant academic research and scientific papers

3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αν- containing i

Palladium-catalyzed regioselective allylation of five-membered heteroarenes with allyltributylstannane

Palladium-catalyzed allylation reactions of 2-(chloromethyl)thiophenes, 2-(chloromethyl)furans, and N-protected 2-(chloromethyl)-1H-pyrroles with allyltributylstannane were described in this study. This type of allylation reaction regioselectively occurred on the heteroarene rings to produce allylated dearomatization products or allylated heteroarenes with satisfactory yields.

SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES

The present invention provides compounds of the general Formula DI: along with methods of making such compounds, formulations containing the same, and methods of using the same (e.g., in photodynamic therapy, for the production of solar cells, etc.).

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517

Based on the lead compound BX-517, a series of C-4′ substituted indolinones have been synthesized and evaluated for PDK1 inhibition. Modification at C-4′ of the pyrrole afforded potent compounds (7b and 7d) with improved solubility and ADME properties. In this letter, we describe the synthesis, selectivity profile, and pharmacokinetic data of selected compounds.

Synthetic chlorins bearing auxochromes at the 3- and 13-positions

Synthetic chlorins bearing diverse auxochromes at the 3- and 13-positions of the macrocycle are valuable targets given their resemblance to chlorophylls a and b, which bear 3-vinyl and 13-keto groups. A de novo route has been exploited to construct nine z

Indolinone derivatives and their use in treating disease-states such as cancer

Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.