850795-41-4Relevant academic research and scientific papers
N-Cyanomethyl-β-chloroamines: A convenient source of aziridinium ions
Couty, Fran?ois,Evano, Gwilherm,Prim, Damien
, p. 2253 - 2257 (2005)
N-Cyanomethyl-β-chloroamines smoothly react with a range of alcohols or amines to give regio- and stereoselectively 1,2-aminoethers or 1,2-diamines. The reaction proceeds through the formation of an intermediate aziridinium ion. The N-cyanomethyl group can then be cleaved easily.
N-Cyanomethyl-β-chloro amines: chiral building blocks for the synthesis of azacrown ethers
Couty, Fran?ois,Evano, Gwilherm,Menguy, Laurence,Steimetz, Vincent,Toumi, Mathieu
, p. 4817 - 4821 (2007/10/03)
(1R,2S)-Ephedrine and norephedrine derived N-cyanomethyl-β-chloro amines react with tri-, tetra- and penta-ethylene glycol to stereoselectively give the corresponding amino ethers. Further transformation into chiral monoaza 12-, 15- and 18-crown-4, -5 and
