850807-89-5Relevant academic research and scientific papers
Symmetrical bis-quinolinium compounds: New human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line
Sánchez-Martín, Rosario,Campos, Joaquín M.,Conejo-García, Ana,Cruz-López, Olga,Bá?ez-Coronel, Mónica,Rodríguez-González, Agustín,Gallo, Miguel A.,Lacal, Juan C.,Espinosa, Antonio
, p. 3354 - 3363 (2005)
Studies have been aimed at the establishment of structure-activity relationships that define choline kinase inhibitory and antiproliferative activities of 40 bisquinolinium compounds. These derivatives have electron-releasing groups at position 4 of the q
DERIVATIVES OF PYRIDINE AND QUINOLINE
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Page/Page column 14, (2008/06/13)
The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatmen
