850899-02-4Relevant academic research and scientific papers
Stereoselective entry to bicyclic β-lactams via free radical cyclization of 2-azetidinone-tethered bromohomoallylic alcohols
Alcaide, Benito,Almendros, Pedro,Rodriguez-Acebes, Raquel
, p. 2335 - 2340 (2005)
Triphenyltin hydride-promoted reaction of β-lactamtethered bromodienes gave six-, seven-, or eight-membered bicyclic ring structures through intramolecular free radical cyclization. The cyclization precursors were synthesized by stereoselective tin-mediated carbonyl bromoallylation of 4-oxoazetidine-2-carbaldehydes in an aqueous environment. Georg Thieme Verlag Stuttgart.
Novel carbonyl bromoallylation/heck reaction sequence. Stereocontrolled access to bicyclic β-lactams
Alcaide, Benito,Almendros, Pedro,Rodriguez-Acebes, Raquel
, p. 2713 - 2719 (2007/10/03)
(Chemical Equation Presented) The reaction of 2,3-dibromopropene with racemic as well as enantiopure 4-oxoazetidine-2-carbaldehydes 1 in aqueous media was promoted by tin in the presence of several additives to afford the corresponding bromohomoallyl alco
