850913-52-9

Basic information

• Product Name: 2-Butenoic acid, 2-hydroxy-4-oxo-4-[2-(phenylmethoxy)phenyl]-, methyl ester
• CAS NO: 850913-52-9
• Molecular Formula: C18H16O5
• Molecular Weight: 312.322
• Mol File: 850913-52-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 2-hydroxy-4-oxo-4-[2-(phenylmethoxy)phenyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 2-hydroxy-4-oxo-4-[2-(phenylmethoxy)phenyl]-, methyl ester(850913-52-9)
• EPA Substance Registry System: 2-Butenoic acid, 2-hydroxy-4-oxo-4-[2-(phenylmethoxy)phenyl]-, methyl ester(850913-52-9)

Safety Data

• Hazardous Substances Data: 850913-52-9(Hazardous Substances Data)

Upstream product

• 553-90-2 Dimethyl oxalate 
• 31165-67-0 2'-benzyloxyacetophenone 

Downstream Products

• 251966-04-8 C₁₇H₁₄O₅ 

Relevant articles and documents

Effects of the aryl linker and the aromatic substituent on the anti-HCV activities of aryl diketoacid (ADK) analogues

Based on our pharmacophore model of the aryl diketoacids (ADKs), we designed and prepared a series of novel ADK analogues, which showed potent inhibitory activities against the NS5B polymerase in the submicromolar range. Pharmacophore-guided docking study revealed that the antiviral activities of the ADKs are highly dependent upon the aryl linker as well as the size and position of the aromatic substituent. It is of another importance that, unlike previously reported ADKs, three ADK analogues synthesized in this study effectively blocked Hepatitis C Virus (HCV) replication in the replicon systems.