85092-72-4Relevant academic research and scientific papers
Synthesis and fluorescence properties of aminocyanopyrrole and aminocyanothiophene esthers for biomedical and bioimaging applications
Agrebi, Asma,Allouche, Fatma,Alves, Sérgio,Baleiz?o, Carlos,Cherif, Oussama,Farinha, José Paulo
, (2020/03/11)
We prepared a series of substituted aminocyanopyrroles and another of aminocynaothiophenes. We describe an efficient new one-step synthetic strategy via the condensation of an alkyl sarcosinate and ethoxymethylenemalononitrile, through a Gewald-like reaction. The UV–visible absorption and steady-state and time resolved fluorescence properties of some representative compounds, as well as their acid-base behavior, is also presented. The compounds might be useful for medicinal applications and as bioimaging probes.
THIENOIMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND USE
-
, (2008/06/13)
Benzimidazole derivatives of the formula (I): STR1 wherein the ring A is a thiophene ring which may optionally contain substitution in addition to the R 3 group; R 1 is hydrogen or an optionally substituted hydrocarbon residue which may be bonded through a heteroatom; R 2 and R 3 are independently a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2; or a salt thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
