85092-83-7

Basic information

• Product Name: 1H-INDOLE, 3-BROMO-5-METHOXY-
• Synonyms: 1H-INDOLE, 3-BROMO-5-METHOXY-;3-Bromo-5-methoxyindole;3-BROMO-5-METHOXY-1H-INDOLE
• CAS NO: 85092-83-7
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.07
• Product Categories: Indole
• Mol File: 85092-83-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 355.6 °C at 760 mmHg
• Flash Point: 168.9 °C
• Appearance: /
• Density: 1.591 g/cm³
• Vapor Pressure: 6.34E-05mmHg at 25°C
• Refractive Index: 1.667
• PKA: 15.04±0.30(Predicted)
• CAS DataBase Reference: 1H-INDOLE, 3-BROMO-5-METHOXY-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE, 3-BROMO-5-METHOXY-(85092-83-7)
• EPA Substance Registry System: 1H-INDOLE, 3-BROMO-5-METHOXY-(85092-83-7)

Safety Data

• Hazardous Substances Data: 85092-83-7(Hazardous Substances Data)

Usage

General Description

1H-Indole, 3-bromo-5-methoxy- is a chemical compound with the molecular formula C9H8BrNO and a molar mass of 230.07 g/mol. It is a brominated derivative of indole with a methoxy group attached to the 5th carbon atom. 1H-INDOLE, 3-BROMO-5-METHOXY- belongs to the class of organic compounds known as indole and derivatives, which are biologically active compounds commonly found in plants and fungi. 1H-Indole, 3-bromo-5-methoxy- has potential applications in pharmaceuticals, agrochemicals, and material science. It is commonly used as a building block in the synthesis of various organic compounds for research and industrial purposes.

InChI:InChI=1/C9H8BrNO/c1-12-6-2-3-9-7(4-6)8(10)5-11-9/h2-5,11H,1H3

Upstream product

• 1006-94-6 5-methoxylindole 

Downstream Products

• 880771-40-4 3-bromo-5-methoxy-1-(phenylsulfonyl)-1H-indole 

Relevant articles and documents

Synthesis and anti-tumor activity of marine alkaloids

Marine alkaloids were divided into five categories from the perspective of anti-tumor activity. The optimization process, chemical synthesis, anti-tumor activity evaluation and structure–activity relationship of various compounds were discussed.

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target. We previously found that dihydrotanshinone

Simple and efficient procedures for selective preparation of 3-haloindoles and 2,3-dihaloindoles by using 1,3-dibromo-5,5-dimethylhydantoin and 1,3-dichloro-5,5-dimethylhydantoin

Simple and efficient synthetic procedures for the selective preparation of 3-bromo/3-chloroindoles and 2,3-dibromo/2,3-dichloroindoles by using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) were developed. Using 1,4-dioxane as the solvent, a variety of indoles, treated with 0.55 equiv DBDMH/DCDMH, afford the corresponding 3-bromo/3-chloroindoles selectively in 82-99% yield. In 1,2-dichloroethane (DCE), a series of 2,3-dichloro/2,3-dibromoindoles were selectively obtained in 84-95% yield by treating with DBDMH/DCDMH. All the processes do not need extra catalysts, dry solvents, or harsh reaction conditions.