850998-10-6

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-[2-[(2-aminoethyl)(methylsulfonyl)amino]phenyl]-, 1,1-dimethylethyl ester
• CAS NO: 850998-10-6
• Molecular Formula: C18H30N4O4S
• Molecular Weight: 398.527
• Mol File: 850998-10-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-[2-[(2-aminoethyl)(methylsulfonyl)amino]phenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-[2-[(2-aminoethyl)(methylsulfonyl)amino]phenyl]-, 1,1-dimethylethyl ester(850998-10-6)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-[2-[(2-aminoethyl)(methylsulfonyl)amino]phenyl]-, 1,1-dimethylethyl ester(850998-10-6)

Safety Data

• Hazardous Substances Data: 850998-10-6(Hazardous Substances Data)

Upstream product

• 52689-15-3 2-iodoethylamine 
• 444582-15-4 1-tert-butoxycarbonyl-4-(2-((methylsulfonyl)amino)phenyl)piperazine 
• 170017-74-0 1-[1,1-dimethylethoxycarbonyl]-4-(2-aminophenyl)piperazine 

Relevant articles and documents

Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides

The biological activity for a set of melanocortin-4 receptor (MC4R) agonists containing a piperazine core with an ortho-substituted aryl sulfonamide is described. Compounds from this set had binding and functional activities at MC4R less than 30 nM. The most selective compound in this series was >25,000-fold more potent at MC4R than MC3R, and 490-fold more potent at MC4R than MC5R. This compound also reduced food intake after oral dosing at 25, 50, and 100 mg kg-1 in fasted mice.