851001-08-6Relevant articles and documents
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition
Burns, David M.,Li, Yun-Long,Shi, Eric,He, Chunhong,Xu, Meizhong,Zhuo, Jincong,Zhang, Colin,Qian, Ding-Quan,Li, Yanlong,Wynn, Richard,Covington, Maryanne B.,Katiyar, Kamna,Marando, Cindy A.,Fridman, Jordan S.,Scherle, Peggy,Friedman, Steve,Metcalf, Brian,Yao, Wenqing
scheme or table, p. 3525 - 3530 (2010/03/24)
A serendipitous discovery that the metalloprotease binding profile of a novel class of 2-carboxamide-3-hydroxamic acid piperidines could be significantly attenuated by the modification of the unexplored P1 substituent enabled the design and synthesis of a
