851008-62-3

Basic information

• Product Name: Sulfoximine, N-(ethoxycarbonyl)-S-ethyl-S-(4-nitrophenyl)-
• CAS NO: 851008-62-3
• Molecular Formula: C11H14N2O5S
• Molecular Weight: 286.309
• Mol File: 851008-62-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Sulfoximine, N-(ethoxycarbonyl)-S-ethyl-S-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfoximine, N-(ethoxycarbonyl)-S-ethyl-S-(4-nitrophenyl)-(851008-62-3)
• EPA Substance Registry System: Sulfoximine, N-(ethoxycarbonyl)-S-ethyl-S-(4-nitrophenyl)-(851008-62-3)

Safety Data

• Hazardous Substances Data: 851008-62-3(Hazardous Substances Data)

Upstream product

• 851008-74-7 (R,S)-S-ethyl-S-(4-nitrophenyl)sulfoximide 
• 541-41-3 chloroformic acid ethyl ester 
• 7205-70-1 (R,S)-1-(ethylsulfinyl)-4-nitrobenzene 
• 7205-60-9 1-(ethylsulfanyl)-4-nitrobenzene 

Downstream Products

• 851007-68-6 (R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-N-(ethoxycarbonyl)-S-ethylsulfoximide 
• 1223498-39-2 (R,S)-S-[4-({5-bromo-4-[(1R,2R)-(2-hydroxy-1-methylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-S-ethylsulfoximide 

Relevant articles and documents

The lab oddity prevails: Discovery of Pan-CDK inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY1000394) for the treatment of cancer

Lead optimization of a high-throughput screening hit led to the rapid identification of aminopyrimidine ZK304709, a multitargeted CDK and VEGF-R inhibitor that displayed a promising preclinical profile. Nevertheless, ZK304709 failed in phaseI studies due

SULFOXIMINE-SUBSTITUTED PYRIMIDINES , THEIR PREPARATION AND USE AS DRUGS

The invention relates to sulfoximine-substituted pyrimidines of the general Formula (I) processes for the preparation thereof and their use as kinase inhibitors for treating for example cancer or inflammation.