85107-14-8Relevant academic research and scientific papers
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors
Frohn, Mike,Viswanadhan, Vellarkad,Pickrell, Alexander J.,Golden, Jennifer E.,Muller, Kristine M.,Buerli, Roland W.,Biddlecome, Gloria,Yoder, Sean C.,Rogers, Norma,Dao, Jennifer H.,Hungate, Randall,Allen, Jennifer R.
scheme or table, p. 5023 - 5026 (2009/05/26)
We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro.
Purines. V. Reaction of 9-Phenyl-9H-purine-6-carbonitrile with Nucleophilic Reagents
Higashino, Takeo,Yoshida, Shizuo,Hayashi, Eisaku
, p. 4521 - 4525 (2007/10/02)
The reaction of phenyl-9H-purine-6-carbonitrile (1) with nucleophilic reagents occurred by addition of the reagent across the C-N triple bond of the cyano group, and substitution of the cyano group was not observed.Thus the reaction with hydroxylamine, hy
