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851199-59-2

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851199-59-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 851199-59-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,1,9 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 851199-59:
(8*8)+(7*5)+(6*1)+(5*1)+(4*9)+(3*9)+(2*5)+(1*9)=192
192 % 10 = 2
So 851199-59-2 is a valid CAS Registry Number.

851199-59-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name linaclotide

1.2 Other means of identification

Product number -
Other names Linaelotide Acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:851199-59-2 SDS

851199-59-2Upstream product

851199-59-2Downstream Products

851199-59-2Relevant academic research and scientific papers

Chemical synthesis and structural analysis of guanylate cyclase C agonist linaclotide

Chen, Chenchen,Gao, Shuai,Qu, Qian,Mi, Pengcheng,Tao, Anjin,Li, Yi-Ming

, p. 1135 - 1138 (2018)

Guanylate cyclase C (GC-C) is an important receptor protein expressed by intestinal epithelial cells, and its dysregulation leads to severe intestinal diseases. Linaclotide is a 14-amino acid peptide approved by the FDA for the treatment of irritable bowel syndrome with constipation (IBS-C), which activates guanylate cyclase C to accelerate intestinal transit. Drug molecule design based on structural information plays a crucial role and the activity of linaclotide still need to improve, while the structure of linaclotide remains unknown. In this work, linaclotide and its D-enantiomer were obtained through Fmoc solid phase peptide synthesis method and co-crystalized through racemic crystallization. The crystal structure showed that linaclotide has a tight, three-beta turns structure immobilized by three pairs of disulfide bonds.

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