85128-46-7

Basic information

• Product Name: Phenol, 2-[1-(1H-imidazol-1-yl)ethenyl]-4,6-dimethyl-
• CAS NO: 85128-46-7
• Molecular Formula: C13H14N2O
• Molecular Weight: 214.267
• Mol File: 85128-46-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phenol, 2-[1-(1H-imidazol-1-yl)ethenyl]-4,6-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-[1-(1H-imidazol-1-yl)ethenyl]-4,6-dimethyl-(85128-46-7)
• EPA Substance Registry System: Phenol, 2-[1-(1H-imidazol-1-yl)ethenyl]-4,6-dimethyl-(85128-46-7)

Safety Data

• Hazardous Substances Data: 85128-46-7(Hazardous Substances Data)

Upstream product

• 1198-66-9 3,5-dimethyl-2-hydroxyacetophenone 
• 3005-50-3 N,N'-Thionyldiimidazole 

Downstream Products

• 85128-22-9 1-[2-(1-Imidazol-1-yl-vinyl)-4,6-dimethyl-phenoxy]-3-isopropylamino-propan-2-ol 
• 85128-21-8 1-tert-Butylamino-3-[2-(1-imidazol-1-yl-vinyl)-4,6-dimethyl-phenoxy]-propan-2-ol 

Relevant articles and documents

Synthesis and antiarrhythmic activity of new 1-[1-[2-[3-(alkylamino)-2-hydroxypropoxy]phenyl]vinyl]-1H-imidazoles and related compounds

Various 1-[1-[2-[3-(alkylamino)-2-hydroxypropoxy]phenyl]vinyl]-1H-azoles were synthesized and investigated for β-adrenoceptor-blocking and antiarrhythmic activities. Although no compounds showed more potent β-blocking effects than propranolol in the isolated guinea pig right atria, many compounds exhibited significant antiarrhythmic effects against aconitine or ischemic arrhythmia in mice or dogs. 1-[2,5-Dichloro-6-[1-(1H-imidazol-1-yl)ethenyl]phenoxy]-3-[(1-methylethyl) amino]-2-propanol hydrochloride (48) (711389-S) was selected as a candidate for clinical evaluation in man, since its antiarrhythmic effects were superior to those of quinidine, disopyramide, or propranolol. Asymmetric synthesis of (R)-(+)- and (S)-(-)-48 is described, and it is proven that there is no stereospecificity in the antiarrhythmic effect of 48.