851316-29-5Relevant articles and documents
Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4- dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents
De Jonghe, Steven,Marchand, Arnaud,Gao, Ling-Jie,Calleja, Agnes,Cuveliers, Eva,Sienaert, Ilse,Herman, Jean,Clydesdale, Gavin,Sefrioui, Hassane,Lin, Yuan,Pfleiderer, Wolfgang,Waer, Mark,Herdewijn, Piet
, p. 145 - 149 (2011)
Screening of a pteridine-based compound library led to the identification of compounds exhibiting immunosuppressive as well as anti-inflammatory activity. Optimization afforded a series of 2-amino-4-N-piperazinyl-6-(3,4- dimethoxyphenyl)pteridine analogues. The most potent congeners in this series displayed low nM IC50 values in the Mixed Lymphocyte Reaction (MLR) assay. In addition, these compounds also have potent anti-inflammatory activity as measured in the Tumor Necrosis Factor (TNF) assay.
