851320-40-6Relevant academic research and scientific papers
Hydrogen-bonded dimers in 3-amino-4-anilino-1H-isochromen-1-one and a hydrogen-bonded sheet in 3-amino-4-[methyl(phenyl)amino]-1H-isochromen-1-one
Vicentes, Daniel E.,Rodriguez, Ricaurte,Cobo, Justo,Glidewell, Christopher
, p. 770 - 773 (2013)
The molecules of 3-amino-4-anilino-1H-isochromen-1-one, C 15H12N2O2, (I), and 3-amino-4-[methyl(phenyl)amino]-1H-isochromen-1-one, C16H 14N2O2, (II), adopt very similar conformations, with the substituted amino group PhNR, where R = H in (I) and R = Me in (II), almost orthogonal to the adjacent heterocyclic ring. The molecules of (I) are linked into cyclic centrosymmetric dimers by pairs of N - H...O hydrogen bonds, while those of (II) are linked into complex sheets by a combination of one three-centre N - H...(O)2 hydrogen bond, one two-centre C - H...O hydrogen bond and two C - H...π(arene) hydrogen bonds.
Facile preparation of 3-amino-4-(arylamino)-1h-isochromen-1-ones by a new multicomponent reaction
Opatz, Til,Ferenc, Dorota
, p. 817 - 821 (2007/10/03)
Reactions between 2-formylbenzoic acid, various anilines and HCN result in the formation of 3-amino-4-(arylamino)-1H-isochromen-1-ones in high yield. The mechanism of this three-component condensation involves the intermediate formation of an α-aminonitrile and subsequent cyclization through nucleophilic attack of the ortho-carboxylate at the nitrile carbon. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
