851320-44-0Relevant academic research and scientific papers
Facile preparation of 3-amino-4-(arylamino)-1h-isochromen-1-ones by a new multicomponent reaction
Opatz, Til,Ferenc, Dorota
, p. 817 - 821 (2005)
Reactions between 2-formylbenzoic acid, various anilines and HCN result in the formation of 3-amino-4-(arylamino)-1H-isochromen-1-ones in high yield. The mechanism of this three-component condensation involves the intermediate formation of an α-aminonitrile and subsequent cyclization through nucleophilic attack of the ortho-carboxylate at the nitrile carbon. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
