851334-92-4

Usage

Uses

Used in Organic Synthesis:
4-Ethoxycarbonyl-2-fluorophenylboronic acid, pinacol ester is used as a reagent in the formation of carbon-carbon and carbon-heteroatom bonds. Its pinacol ester group provides stability and enhances its reactivity, making it suitable for cross-coupling reactions and the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Ethoxycarbonyl-2-fluorophenylboronic acid, pinacol ester is used as a key intermediate for the production of active pharmaceutical ingredients. Its unique structure and reactivity enable the synthesis of novel drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
4-Ethoxycarbonyl-2-fluorophenylboronic acid, pinacol ester is also utilized in the agrochemical industry for the synthesis of agrochemical products. Its versatility in organic synthesis allows for the development of new and effective agrochemicals for crop protection and pest control.
Used in Material Science:
In the field of material science, 4-Ethoxycarbonyl-2-fluorophenylboronic acid, pinacol ester is employed in the development of new materials and catalysts. Its unique properties and reactivity contribute to the creation of advanced materials with improved performance and functionality.
Overall, 4-Ethoxycarbonyl-2-fluorophenylboronic acid, pinacol ester is an important and versatile compound in the field of organic chemistry, with applications spanning across various industries, including pharmaceuticals, agrochemicals, and material science. Its unique structure and reactivity make it a valuable tool for the synthesis of complex organic molecules and the development of innovative products.

Upstream product

• 451-02-5 ethyl 3-fluorobenzoate 
• 73183-34-3 bis(pinacol)diborane 
• 455-38-9 3-fluorobenzoic acid 

Relevant academic research and scientific papers

Ligand-Enabled, Iridium-Catalyzed ortho-Borylation of Fluoroarenes

A terpyridine derivative and an iridium complex catalyze the C-H borylation of a stoichiometric amount of a fluoroarene with high ortho-selectivity and tolerance of functional groups such as bromide, chloride, ester, ketone, amine, and in situ-borylated hydroxyl. Complex drug molecules such as haloperidol can be selectively borylated ortho to the F atom. The terpyridine ligand undergoes rollover cyclometalation to produce an N,N,C-coordinated iridium complex, which may either selectively borylate the fluoroarene by itself or undergo reductive elimination to produce a borylated ligand.

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

C(sp2)-H Borylation of Fluorinated Arenes Using an Air-Stable Cobalt Precatalyst: Electronically Enhanced Site Selectivity Enables Synthetic Opportunities

Cobalt catalysts with electronically enhanced site selectivity have been developed, as evidenced by the high ortho-to-fluorine selectivity observed in the C(sp2)-H borylation of fluorinated arenes. Both the air-sensitive cobalt(III) dihydride boryl 4-Me-(iPrPNP)Co(H)2BPin (1) and the air-stable cobalt(II) bis(pivalate) 4-Me-(iPrPNP)Co(O2CtBu)2 (2) compounds were effective and exhibited broad functional group tolerance across a wide range of fluoroarenes containing electronically diverse functional groups, regardless of the substitution pattern on the arene. The electronically enhanced ortho-to-fluorine selectivity observed with the cobalt catalysts was maintained in the presence of a benzylic dimethylamine and hydrosilanes, overriding the established directing-group effects observed with precious-metal catalysts. The synthetically useful selectivity observed with cobalt was applied to an efficient synthesis of the anti-inflammatory drug flurbiprofen.

AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE

The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R4, R5 and R6 is independently hydrogen, halogen, lower alkyl or lower alkoxy; R7 is hydrogen or lower alkyl; R8 is hydrogen, halogen, lower alkyl, lower alkoxy, etc; R9 is -COR10, -A1-COR10, -O-A2-COR10, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, -OCH2-, etc, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.