851371-08-9Relevant academic research and scientific papers
Highly efficient catalytic asymmetric Sulfa-Michael addition of thiols to trans-4,4,4-trifluorocrotonoylpyrazole
Dong, Xiu-Qin,Fang, Xin,Tao, Hai-Yan,Zhou, Xiang,Wang, Chun-Jiang
supporting information; experimental part, p. 1141 - 1147 (2012/05/20)
A new protocol for the efficient construction of chiral trifluoromethylated building blocks was developed via organocatalyzed sulfa-Michael addition of thiols to the cost-efficient trans-trifluorocrotonamide. Introducing the pyrazole moiety is crucial to providing H-bond acceptor sites for better activation and hence affording comparable asymmetric induction with that obtained when employing the expensive cis-4,4,4-trifluorocrotonate as the Michael acceptor. Copyright
Novel highly potent, structurally simple γ-trifluoromethyl γ-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3)
Sani, Monica,Candiani, Gabriele,Pecker, Fran?oise,Malpezzi, Luciana,Zanda, Matteo
, p. 2393 - 2396 (2007/10/03)
The γ-trifluoromethyl γ-sulfone hydroxamate 1 was synthesized both in racemic and enantiomerically pure forms by means of a thia-Michael reaction of p-methoxythiophenol on achiral and chiral 3,3,3-trifluorocrotonoyl Michael acceptors. The (R)-1 enantiomer
