851371-60-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)is utilized as an intermediate in the synthesis of various pharmaceutical drugs. Its unique structure allows it to be a key component in the development of new medications, particularly those targeting specific medical conditions. Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)-'s potential biological activity makes it a promising candidate for further research and development in the pharmaceutical sector.
Used in Agrochemical Industry:
In the agrochemical industry, Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)is employed in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties enable it to be a valuable component in the formulation of these products, contributing to their effectiveness in controlling pests and weeds in agricultural settings.
Used in Organic Synthesis:
Due to its unique chemical structure, Ethanone, 1-(2-furanyl)-2-(4-pyrimidinyl)is also used as a building block in the synthesis of other organic compounds. Its versatility allows it to be incorporated into a wide range of chemical reactions, making it a valuable asset in the field of organic chemistry. This application further expands the potential uses of the compound across various industries.

InChI:InChI=1/C10H8N2O2/c13-9(10-2-1-5-14-10)6-8-3-4-11-7-12-8/h1-5,7H,6H2

Upstream product

• 3438-46-8 4-Methylpyrimidine 
• 614-99-3 Ethyl 2-furoate 

Downstream Products

• 851371-58-9 4'-(2-furyl)-4,5'-bipyrimidin-2'-amine 

Relevant academic research and scientific papers

Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A2B adenosine receptor antagonists

The synthesis and SAR of a series of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent A2B adenosine receptor antagonists is described. Several compounds showed good selectivity versus other adenosine receptors. The potent and selective analogue 9 was shown to have good oral bioavailability in the rat.

PYRAZINE DERIVATIVES USEFUL AS ADENOSINE RECEPTOR ANTAGONISTS

The present invention provides a compound of formula (I) wherein: A represents an optionally substituted monocyclic or polycyclic aryl or heteroaryl group B represents an optionally substituted monocyclic nitrogen-containing heteroaryl group ; and either a) R1 and R2 represent hydrogen or specified substituents, or b) R2, R1 and the -NH- group to which R1 is attached, form a moiety selected from the moiety of formulae (IIa) and (IIb): (IIa) These compounds are useful as antagonists of the A2B receptor, for instance in the treatment of asthma.

Discovery and characterization of 4′-(2-furyl)-N-pyridin-3-yl-4, 5′-bipyrimidin-2′-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist

A novel series of N-heteroaryl 4′-(2-furyl)-4,5′-bipyrimidin- 2′-amines has been identified as potent and selective A2B adenosine receptor antagonists. In particular, compound 5 showed high affinity for the A2B receptor (Ki = 17 nM), good selectivity (IC50: A1 > 1000 nM, A2A > 2500 nM, A3 > 1000 nM), displayed a favorable pharmacokinetic profile in preclinical species, and showed efficacy in functional in vitro models.

CONDENSED PYRIDINE DERIVATIVES USEFUL AS A28 ADENOSINE RECEPTOR ANTGONISTS

The present invention relates to new antagonists of the A2B adenosine receptor represented by formula (I). Those compounds are useful for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the A2B adenosine receptor such as asthma, bronchoconstriction, allergic diseases, hypertension, atherosclerosis, reperfusion injury, myocardial ischemia, retinopathy, inflammation, gastrointestinal tract disorders, cell proliferation disorders, diabetes mellitus, and/or autoimmune diseases.

PYRIMIDIN-2-AMINE DERIVATES AND THEIR USE AS A2B ADENOSINE RECEPTOR ANTAGONISTS

This invention is directed to new potent and selective antagonists of the A2B adenosine receptor having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.