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8(9)-EpETE, an epoxygenase pathway product derived from eicosapentaenoic acid (EPA), is produced by cytochrome P450 (CYP450) enzymes both in vitro and in vivo. Its biological actions and physiological effects are still under investigation.

851378-93-3

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851378-93-3 Usage

Uses

Used in Pharmaceutical Industry:
8(9)-EpETE is used as a potential therapeutic agent for various conditions due to its role as an epoxygenase pathway product. Its biological actions and physiological effects are being studied to determine its potential applications in treating specific diseases or conditions.
Used in Research Applications:
8(9)-EpETE is used as a research tool to investigate the role of epoxyeicosatetraenoic acids (EpETEs) in biological processes and their potential as therapeutic agents. This helps researchers to better understand the mechanisms of action and the potential benefits of these compounds in various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 851378-93-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,3,7 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 851378-93:
(8*8)+(7*5)+(6*1)+(5*3)+(4*7)+(3*8)+(2*9)+(1*3)=193
193 % 10 = 3
So 851378-93-3 is a valid CAS Registry Number.

851378-93-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-(3-undeca-2,5,8-trienyloxiran-2-yl)hept-5-enoic acid

1.2 Other means of identification

Product number -
Other names 8,9-epoxieicosatetraenoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:851378-93-3 SDS

851378-93-3Downstream Products

851378-93-3Relevant academic research and scientific papers

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450

Lucas, Daniele,Goulitquer, Sophie,Marienhagen, Jan,Fer, Maude,Dreano, Yvonne,Schwaneberg, Ulrich,Amet, Yolande,Corcos, Laurent

experimental part, p. 1125 - 1133 (2010/09/16)

Cytochromes P450 (CYPs) metabolize polyun-saturated long-chain fatty acids (PUFA-LC) to several classes of oxygenated metabolites. Through use of human recombinant CYPs, we recently showed that CYP1A1, -2C19, -2D6, -2E1, and -3A4 are mainly hydroxylases, whereas CYP1A2, -2C8, -2C9, and -2J2 are mainly epoxygenases of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), respectively. It is worth noting that the last double bond of these PUFAs, i.e., ω6 in AA or ω3 in EPA and DHA, respectively, was preferentially epoxidized. In this study, we have characterized the stereoselectivity of this epoxidation reaction by comparison with the PUFA-LC epoxide stereoisomers obtained from the enantioselective bacterial CYP102A1 F87V. The stereoselectivity of the epoxidation of the last olefi n of AA (ω6), EPA (ω3), or DHA (ω3) differed between the CYP isoforms but was similar for EPA and DHA. These data give additional insight into the PUFA-LC epoxide enantiomers generated by the hepatic CYPs. Copyright

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