851402-37-4

Upstream product

• 20240-61-3 cis/trans-4-methyl-1,2,3,4-tetrahydro-1-naphthol 
• 91083-82-8 (E)-methyl 4-phenylbut-3-enoate 
• 19832-98-5 4-methyl-3,4-dihydro-2H-naphthalen-1-one 
• 98213-30-0 1-methyl-1,2-dihydronaphthalene 
• 119987-21-2 (E)-methyl 2-diazo-4-phenylbut-3-enoate 

Relevant academic research and scientific papers

Direct synthesis of (+)-erogorgiaene through a kinetic enantiodifferentiating step

(Chemical Equation Presented) The combined approach of C-H activation and a Cope rearrangement catalyzed by a rhodium catalyst [Rh2(R-dosp) 4] (dosp = (N-dodecylbenzenesulfonyl)prolinate) is shown to be a very effective method for the construction of the three stereogenic centers (marked in red, see scheme) present in the diterpene erogorgiaene (1).

Erogorgiaene congeners and methods and intermediates useful in the preparation of same

Disclosed are compounds having the formula: wherein R21 is an alkyl, aryl, alkoxy, hydroxy, or amino group or a halogen atom; wherein R2 is hydrogen or an alkyl, aryl, alkoxy, or amino group; wherein R23 and R24 are independently selected from hydrogen, an alkyl, aryl, alkoxy, hydroxy, or amino group, and a halogen atom or wherein R23 and R24, taken together with the carbon atom to which they are bound, form a ring; wherein R25 is hydrogen, an alkyl, aryl, alkoxy, hydroxy, or O-silyl group or a halogen atom; wherein Z, taken together with the carbons to which it is bonded, forms a 5-12 membered ring; and wherein Y is an electron withdrawing group. These compounds can be used to prepare erogorgiaene congeners, such as erogorgiaene, pseudopterosin A, helioporin E, pseudopteroxazole, colombiasin A, elisapoterosin B, elisabethadione, p-benzoquinone natural products, ileabethin, sinulobtain B, sinulobtain C, and sinulobtain D.