851520-56-4

Basic information

• Product Name: 3-tert-butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide
• CAS NO: 851520-56-4
• Molecular Weight: 266.73
• Mol File: 851520-56-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-tert-butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-tert-butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide(851520-56-4)
• EPA Substance Registry System: 3-tert-butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide(851520-56-4)

Safety Data

• Hazardous Substances Data: 851520-56-4(Hazardous Substances Data)

Upstream product

• 1027831-91-9 3-tert-Butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride 
• 959581-99-8 diethyl 2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-ylamino)methylene]malonate 
• 1026971-98-1 3-tert-Butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 1027509-13-2 3-tert-Butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 118430-73-2 5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine 

Relevant articles and documents

Discovery of new orally active phosphodiesterase (PDE4) inhibitors

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.