851527-76-9Relevant academic research and scientific papers
Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships
Zhao, Chen,Sun, Minghua,Bennani, Youssef L.,Miller, Thomas R.,Witte, David G.,Esbenshade, Timothy A.,Wetter, Jill,Marsh, Kennan C.,Hancock, Arthur A.,Brioni, Jorge D.,Cowart, Marlon D.
experimental part, p. 4640 - 4649 (2010/03/01)
A new histamine H3 receptor (H3R) antagonist chemotype 1 was designed by combining key pharmacophoric elements from two different precursor structural series and then simplifying and optimizing the resulting combined structural featu
