85157-57-9

Usage

Explanation

The compound's full name, which includes its stereochemistry and substituents.

Explanation

The compound belongs to the class of diols, which are organic compounds with two hydroxyl (OH) groups.

Explanation

An alternative name for the compound, which is derived from its structure and the presence of ethyl groups.

Explanation

The compound is used in various industries, such as pharmaceuticals, cosmetics, and plastics, as a solvent and stabilizer. It also promotes adhesion in coatings and adhesives.

Explanation

The compound appears as a transparent, colorless liquid at room temperature.

Explanation

The compound has a subtle, not very strong odor.

Explanation

The compound does not readily undergo chemical reactions or decomposition under typical environmental conditions.

Explanation

The compound is considered to be less toxic than many other chemicals, making it a safer option for various applications.

Category

Diols

Applications

Solvent, stabilizer, coatings, and adhesives

Physical State

Clear, colorless liquid

Odor

Faint

Stability

Relatively stable under normal conditions

Toxicity

Low toxicity level

Upstream product

• 557-20-0 diethylzinc 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 925-90-6 ethylmagnesium bromide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 170379-92-7 (1S)-1-(2-bromophenyl)propan-1-ol 
• 679420-05-4 (R)-3-ethyl-2-oxaindan-1-ol 
• 403656-44-0 (S)-2-[1-(4-methoxybenzyloxy)propyl]benzaldehyde 
• 403656-45-1 C₁₇H₁₉BrO₂ 

Downstream Products

• 679420-13-4 (1S,5S)-1,5-diethyl-3-phenyl-1,5-dihydro-benzo[e][1,3,2]dioxa-phosphepine-3-oxide 
• 679430-36-5 (1R,5S)-1,5-diethyl-3-phenyl-1,5-dihydro-benzo[e][1,3,2]dioxa-phosphepine-3-oxide 

Relevant academic research and scientific papers

Optical resolution of C2-symmetric racemic 1,4-diols with o-xylylene structure by chiral resolving agent (S)-ALBO-V

Optical resolution of C2-symmetric racemic 1,4-diols, 1,2-bis(1-hydroxyalkyl)benzene, was examined using (S)-5-allyl-2-oxabicyclo[3.3.0]octene ((S)-ALBO-V) as chiral resolving agent. Diastereomeric acetals obtained from the 1,4-diols with (S)-A

NEW CHIRAL DIOLS, THEIR MANUFACTURE AND LIGANDS AND CATALYSTS DERIVED THEREFROM

The present invention relates to a method for the preparation of C2-symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R1 and R2 have the meanings given in the specification, that makes use of the metallation of pure enantiomers of α-(aryl or heteroaryl)-α-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C2--symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.

Synthesis of α,β-unsaturated dioxanes, dioxolanes and dioxepanes by trans-acetalisation of dimethylacetals with meso or C 2-symmetrical 1,2-, 1,3- and 1,4-diols

Several o-dibenzylic diols were prepared reacting organometallics with o-phthalaldehyde at room temperature in ether. The identity of the meso and C2-symmetrical (D,L) isomers as well as their ratio were determined by chiral gas chromatography. The meso and C2 (racemic) stereoisomeric diols were easily separated by flash chromatography on silica gel. A set of 18 α,β-unsaturated acetals were then prepared reacting those, as well as commercially available 1,2, 1,3 and 1,4 diols, with the corresponding methylacetals in acidic medium. A trans-acetalisation procedure adapted to the cases of fragile allylic alcohols or unfavorable 1,6 diols-derived dioxonanes based on a Dean-Stark trapping of methanol was also employed.

An efficient enantioselective preparation of (S,S)-1,2-bis(1-hydroxyalkyl)benzene

(S,S)-1,2-Bis(1-hydroxyalkyl)benzenes were obtained in >99% ee's with high diastereoselectivity by the enantioselective addition of dialkylzinc to (S)-2-[1-(4-methoxybenzyloxy)alkyl]-benzaldehyde (86% ee) in the presence of a catalytic amount of (S)-2-(4-

Enantioselective dialkylation of 1,2-phthalicdicarboxaldehyde

A new two-step, one-pot procedure is reported for the enantioselective synthesis of C2-symmetric diols derived from 1,2-phthalicdicarboxaldehyde. The first step involves the enantioselective addition of a dialkylzinc compound to one of the aldehyde groups, affording a lactol organozinc derivative. In the second step this lactol derivative is converted to the appropriate diol with the aid of a Grignard reagent and subsequent hydrolysis. This methodology also allows the synthesis of unsymmetric diols.

Asymmetric synthesis of chiral diols by the catalytic enantioselective dialkylation of tere-, iso-, and phthalaldehydes and by a catalytic enantioselective autoinductive reaction

Optically pure aromatic diols were synthesized by the highly enantioselective dialkylation of aromatic dialdehydes with dialkylzincs in the presence of a catalytic amount of chiral aminoalcohol 1 or chiral thiophosphoramide alcohol 2 with Ti(0-i-Pr)4. The chiral titanium(IV) alkoxide of 4b, a diisopropylated product of isophthalaldehyde, catalyzed the addition of diisopropylzinc to isophthalaldehyde to gave a chiral zinc alkoxide of 4b with the same configuration by an enantioselective autoinductive reaction (up to 44% e.e.).