851615-67-3

Upstream product

• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 169105-65-1 <3aS, 9bR>-(+)-1,3a-4,9a-tetrahydro-cis-3H-<1>benzopyrano<4,3-c>isoxazole 
• 851615-60-6 (-)-(1'R,2'S,3aS,9bR)-methyl 2'-(3,3a,4,9b-tetrahydro-1H-chromeno[4,3-c]isoxazole-1'-yl)cyclohexanecarboxylate 

Downstream Products

• 851615-68-4 [2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-(3a,9b-dihydro-3H,4H-chromeno[4,3-c]isoxazol-1-yl)-methanone 

Relevant academic research and scientific papers

Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation to mono-protected 1,4-diols

A new and efficient desymmetrisation of bi- and tricyclic meso-anhydrides is described, providing good yields and diastereoselectivities in all cases (routinely >95% de). Derivatisation of the chiral compounds synthesised is then demonstrated by their conversion into mono-protected 1,4-diols.