851651-84-8

Basic information

• Product Name: 3-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)propanamide
• Synonyms: 3-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)propanamide
• CAS NO: 851651-84-8
• Molecular Weight: 292.338
• Mol File: 851651-84-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)propanamide(851651-84-8)
• EPA Substance Registry System: 3-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)propanamide(851651-84-8)

Safety Data

• Hazardous Substances Data: 851651-84-8(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 19313-88-3 3-chloro-N-(4-nitrophenyl)propanamide 
• 7766-38-3 N-(4-nitrophenyl) acrylamide 

Relevant articles and documents

Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells

A series of 4,5-di-substituted acridones have been designed and synthesized. Several compounds show high affinity for telomeric G-quadruplex DNA in classical and competition FRET assays, together with low duplex DNA affinity, although they do not show activity in a telomerase assay or evidence of telomere shortening. They have low toxicity against a panel of cancer cell lines and a normal human fibroblast line, and produce potent senescence-based long-term growth arrest in the MCF7 and A549 cancer cell lines.

COMPOUNDS

A compound of formula (I): compositions and medicaments containing the same as well as processes for the preparation and use of such compounds, compositions and medicaments, particularly in diseases associated with inappropriate Aurora activity.