851675-79-1Relevant academic research and scientific papers
N-(4-{[4-(1H-Benzoimidazol-2-yl)-arylamino]-methyl}-phenyl)-benzamide derivatives as small molecule heparanase inhibitors
Xu, Yong-Jiang,Miao, Hua-Quan,Pan, Weitao,Navarro, Elizabeth C.,Tonra, James R.,Mitelman, Stan,Camara, M. Margarita,Deevi, Dhanvanthri S.,Kiselyov, Alexander S.,Kussie, Paul,Wong, Wai C.,Liu, Hu
, p. 404 - 408 (2006)
A novel class of N-(4-{[4-(1H-benzoimidazol-2-yl)-arylamino]-methyl}- phenyl)-benzamides are described as inhibitors of the endo-β-glucuronidase heparanase. Among them are N-(4-{[4-(1H-benzoimidazol-2-yl)-phenylamino]-methyl} -phenyl)-3-bromo-4-methoxy-benzamide (15h), and N-(4-{[5-(1H-benzoimidazol-2-yl) -pyridin-2-ylamino]-methyl}- phenyl)-3-bromo-4-methoxy-benzamide (23) which displayed good heparanase inhibitory activity (IC50 0.23-0.29 μM), with the latter showing oral exposure in mice.
(BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY
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Page/Page column 32, (2010/02/11)
The present invention encompasses heparanase inhibitors, particularly to certain (benzimidazol-2-yl)-phenyl-phenyl-urea derivatives that inhibit heparanase, pharmaceutical compositions that contain the compounds, methods for making the compounds, and meth
