851679-82-8Relevant academic research and scientific papers
Lipase-catalyzed separation of the enantiomers of 1-substituted-3-arylthio- 2-propanols
Wielechowska, Monika,Plenkiewicz, Jan
, p. 1199 - 1205 (2007/10/03)
Optically active (R)- and (S)-1-substituted-3-(arylthio)propan-2-ols have been prepared in the reaction of the appropriate 2-(arylthiomethyl)oxiranes with chloride and azide anions followed by a lipase-catalyzed transesterification. The effects of the enzyme preparation as well as of the reaction conditions have been compared in terms of the enantiomeric excess of the obtained acetate and unreacted alcohol.
