85169-02-4

Usage

Uses

Used in Scientific Research:
3-(4-FLUOROPHENOXY)PROPIONITRILE 97 is used as a research chemical for conducting various scientific experiments and studies. Its high purity level ensures that the results obtained are reliable and accurate, contributing to the advancement of knowledge in the field.
Used in Chemical Synthesis:
3-(4-FLUOROPHENOXY)PROPIONITRILE 97 is used as a key intermediate in the synthesis of other complex molecules and compounds. Its reactivity, due to the presence of fluorine, allows for a wide range of chemical reactions, making it a valuable component in the production of various chemical products.
Used in Pharmaceutical Development:
3-(4-FLUOROPHENOXY)PROPIONITRILE 97 is used as a starting material in the development of new pharmaceutical drugs. Its unique structure and properties can be exploited to create novel drug candidates with potential therapeutic applications, contributing to the discovery of new treatments for various diseases and conditions.

InChI:InChI=1/C9H8FNO/c10-8-2-4-9(5-3-8)12-7-1-6-11/h2-5H,1,7H2

Upstream product

• 371-41-5 4-Fluorophenol 
• 107-13-1 acrylonitrile 

Downstream Products

• 1220893-39-9 6-fluoro-2-phenylchroman-4-one 
• 67146-05-8 sorbinil 
• 66892-34-0 6-fluoro-4-chromanone 
• 69684-83-9 (+/-)-sorbinil 
• 116753-54-9 3-(4-fluorophenoxy)propan-1-amine 
• 1579-78-8 3-(4-fluoro-phenoxy)propionic acid 

Relevant academic research and scientific papers

Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones

3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method involves simple work up and amenable for large scale preparations. The heterogeneous acid treated catalyst can be regenerated and used for up to three cycles with minimum loss of activity.

CHROMENE DERIVATIVES AS INHIBITORS OF TCR-NCK INTERACTION

The present invention provides compounds that modulate the interaction of TCR with Nck, compositions thereof, and methods of treatment using the same.

Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot β-Arylation of Chromanones with Arylboronic Acids

A total of 47 flavanones were expediently synthesized via one-pot β-arylation of chromanones, a class of simple ketones possessing chemically unactivated β sites, with arylboronic acids via tandem palladium(II) catalysis. This reaction provides a novel route to various flavanones, including natural products such as naringenin trimethyl ether, in yields up to 92percent.

Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure-activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.

Process for preparing 6-fluoro-4-chromanone using 3-(4-fluorophenoxy)propionitrile

The present invention relates to 3-(4-fluorophenoxy)propionitrile having the formula (I): STR1 a process for preparing 3-(4-fluorophenoxy)propionitrile having the formula (I) which comprises reacting 4-fluorophenol and acrylonitrile in the presence of a tertiary amine, a process for preparing 6-fluoro-4-chromanone having the formula (II): STR2 which comprises reacting 3-(4-fluorophenoxy)propionitrile having the formula (I) with an acid, and a process for preparing 6-fluoro-4-chromanone having the formula (II) which comprises reacting 4-fluorophenol with acrylonitrile in the presence of a catalyst to give 3-(4-fluorophenoxy)propionitrile having the formula (I), which is then reacted with an acid. 6-Fluoro-4-chromanone is an important intermediate for the synthesis of (S)-2,3-dihydro-6-fluoro-spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'dione (USAN: sorbinil).

Novel thiazolidine derivatives

The invention relates to with novel thiazolidine derivatives of the formula STR1 wherein X is methylene, oxygen or sulfur; R1 is halogen; R2 is hydrogen, nitro, cyano, OR3 or NHR3 ; or R1 and R2 both simultaneously are hydrogen or nitro; R3 is hydrogen, alkyl, acyl, --CO--OR4 or --CO--NHR4 ; and R4 is alkyl, unsubstituted or substituted aryl or aralkyl, and their salts with physiologically compatible cations. The compounds of formula I are useful in the treatment of metabolic disorders.