851713-82-1

Basic information

• Product Name: Fmoc-Tyr(t-Bu)-dimethylpropargyl ester
• Synonyms: Fmoc-Tyr(t-Bu)-dimethylpropargyl ester
• CAS NO: 851713-82-1
• Molecular Weight: 525.645
• Mol File: 851713-82-1.mol

Chemical Properties

• CAS DataBase Reference: Fmoc-Tyr(t-Bu)-dimethylpropargyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Tyr(t-Bu)-dimethylpropargyl ester(851713-82-1)
• EPA Substance Registry System: Fmoc-Tyr(t-Bu)-dimethylpropargyl ester(851713-82-1)

Safety Data

• Hazardous Substances Data: 851713-82-1(Hazardous Substances Data)

Upstream product

• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 

Downstream Products

• 851713-94-5 Fmoc-Tyr(t-Bu)-1,1-dimethylallyl ester 

Relevant articles and documents

A convenient, general synthesis of 1,1-dimethylallyl esters as protecting groups for carboxylic acids

(Chemical Equation Presented) Carboxylic acids were converted in high yield to their 1,1-dimethylallyl (DMA) esters in two steps. Palladium-catalyzed deprotection of DMA esters was shown to be compatible with tert-butyl, benzyl, and Fmoc protecting groups, and Fmoc deprotection could be carried out selectively in the presence of DMA esters. DMA esters were also shown to be resistant to nucleophilic attack, suggesting that they will serve as alternatives to tert-butyl esters when acidic deprotection conditions need to be avoided.