851755-91-4

Upstream product

• 85-44-9 phthalic anhydride 
• 851755-87-8 3-benzyloxy-4-methoxy-benzaldehyde O-(2-hydroxy-2-naphthalen-2-yl-ethyl)-oxime 
• 851755-89-0 (S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enylamine 
• 851755-90-3 2-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]-isoindole-1,3-dione 
• 851755-88-9 (R)-2-{N-[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enyl]aminooxy}-1-naphthalen-2-yl-ethanol 

Downstream Products

• 851755-92-5 (S)-1-(3-Benzyloxy-4-methoxy-phenyl)-2-(2-methyl-[1,3]dioxolan-2-yl)-ethylamine 
• 851755-96-9 C₁₈H₂₅NO₄ 
• 851755-95-8 5-[(7S,9S)-9-(4-Hydroxy-butyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol 
• 851755-97-0 (4S,9aS)-4-(3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl)hexahydro-1H-quinolizin-2(6H)-one 
• 851755-98-1 (2S,4S,9aS)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-octahydro-quinolizin-2-ol 
• 851755-94-7 5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol 
• 851755-93-6 [(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-[(E)-5-benzyloxy-pent-2-en-(E)-ylidene]-amine 
• 33187-34-7 (4S,9aS)-4-(3-hydroxy-4-methoxyphenyl)hexahydro-1H-quinolizin-2(6H)-one 

Relevant academic research and scientific papers

Asymmetric synthesis of (+)-abresoline

The first asymmetric synthesis of (+)-abresoline has been achieved starting from the (S)-1-(aryl)homoallylic amine, which was prepared enantioselectively by the method based on allylation of the (R)-2′-(2-naphthyl)-bearing hydroxyoxime ether. This synthetic route employs the TiCl4-induced intramolecular Mannich-type cyclization of the 1-azadiene-bearing ketal amine as the key steps to afford stereoselectively the cis-2,6-disubstituted piperidine, followed by CBr4/PPh3-induced dehydrocyclization for the elaboration of the amino alcohol to the trans-4-arylquinolizidine.