851764-30-2Relevant articles and documents
Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: Tandem aminoxylation/O-N bond heterolysis reactions
Ramachary, Dhevalapally B.,Barbas III, Carlos F.
, p. 1577 - 1580 (2005)
(Chemical Equation Presented) A practical organocatalytic process for the synthesis of optically active, highly substituted α-hydroxy-ketones was achieved through asymmetric desymmetrization (ADS) of prochiral ketones. The ADS and O-N bond reduction reaction of prochiral ketone with nitrosobenzene in the presence of a catalytic amount of chiral amine or amino acid produced the tandem ADS/O-N bond reduced products as single diastereomers with good yields and excellent enantiomeric excesses.