851811-35-3

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 16532-79-9 4-Bromophenylacetonitrile 
• 883564-47-4 2-amino-3-(p-bromophenyl)-1,8-naphthyridine 

Downstream Products

• 883564-49-6 2-chloro-3-(p-bromophenyl)-1,8-naphthyridine 
• 883564-64-5 N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine 
• 883564-63-4 N-[3-(4-Bromo-phenyl)-[1,8]naphthyridin-2-yl]-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 883564-62-3 N-[3-(4-Bromo-phenyl)-[1,8]naphthyridin-2-yl]-N'-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 883564-55-4 N-[3-(4-bromo-phenyl)-[1,8]naphthyridin-2-yl]-N'-(4-methyl-benzylidene)-hydrazine 
• 883564-56-5 N-[3-(4-Bromo-phenyl)-[1,8]naphthyridin-2-yl]-N'-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine 
• 883564-60-1 N-[3-(4-Bromo-phenyl)-[1,8]naphthyridin-2-yl]-N'-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 883564-59-8 N-[3-(4-Bromo-phenyl)-[1,8]naphthyridin-2-yl]-N'-[1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazine 
• 883564-52-1 N-[3-(4-Bromo-phenyl)-[1,8]naphthyridin-2-yl]-N'-[1-phenyl-meth-(E)-ylidene]-hydrazine 
• 883564-51-0 2-hydrazino-3-(p-bromophenyl)-1,8-naphthyridine 

Relevant academic research and scientific papers

An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity

The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.

Synthesis of 1,2,4-triazolo[4,3-a][1,8]naphthyridines using chloranil under microwave irradiation

A simple and highly efficient procedure has been described for the synthesis of 1-aryl-4-[p-bromophenyl)-1,2, 4-triazolo[4,3-a][1,8]naphthyridines (8) by the oxidation of the corresponding aryl aldehyde 3-(p-bromophenyl)-1, 8-naphthyridin-2-ylhydrazones (7) with chloranil under microwave irradiation. The products are obtained in good yields and in a state of high purity.